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IDP work group charter

Intrinsically Disordered Proteins Working Group Charter

Submitted: 2019-08-20
Template Rev2016b

1. Administrative Section

Status (New/Update): New

Group Name:

HUPO PSI Intrinsically Disordered Proteins Working Group (PSI-IDP WG)

Chair (with affiliation and current email address):
Norman Davey – The Institute of Cancer Research, London, UK (norman.davey@icr.ac.uk)

Co-Chairs (1 or 2) (with affiliation and current email address):
Silvio C. E. Tosatto – University of Padua, Padua, Italy (silvio.tosatto@unipd.it)

Zsuzsanna Dosztányi – Eötvös Loránd University, Budapest, Hungary (dosztanyi@caesar.elte.hu)

Secretary:
Bálint Mészáros – Eötvös Loránd University, Budapest, Hungary (bmeszaros@caesar.elte.hu)

Other officers (optional) (with affiliation and current email address):

Editor(s): Nicolás Palopoli – Universidad Nacional de Quilmes, Buenos Aires, Argentina (npalopoli@unq.edu.ar), Rita Pancsa – Research Centre for Natural Sciences, HAS, Budapest, Hungary (pancsa.rita@ttk.mta.hu), Kim Van Roey – European Molecular Biology Laboratory, Heidelberg, Germany (kimvanroey@hotmail.com)

Minimal Reporting Requirements Coordinator(s): Norman Davey – The Institute of Cancer Research, London, UK (norman.davey@icr.ac.uk)

Ontology Coordinator(s): Toby Gibson – European Molecular Biology Laboratory, Heidelberg, Germany (toby.gibson@embl.de); Peter Tompa – Vrije Universiteit Brussel, Brussels, Belgium (peter.tompa@vub.be)

Website Maintainer(s): Damiano Piovesan – University of Padua, Padua, Italy (damiano.piovesan@unipd.it)

Mailing list
psi-idp-dev@ebi.ac.uk

2. Description and objectives

Focus and Purpose

The PSI-IDP working group is composed of academic, government, and industry researchers, software developers, and database curators and managers. The main goals of the PSI-IDP working group are to:

  • define the community PSI-IDP XML, JSON and TAB exchange formats to permit the dissemination and storage of data relating to Intrinsically Disordered Proteins/Regions (IDP/IDR) structure and function.
  • define the Minimum Information About Disordered Experiments (MIADE) guidelines to standardise the description of IDP experiments.
  • create the ontologies and controlled vocabularies required to define the functional and structural aspects of IDRs, and the technical aspects of the exchange formats and minimum information guidelines.
  • define the best practice guidelines for the curation of IDP literature and the annotation of IDP data.
  • support the implementation of the PSI-IDP exchange formats, controlled vocabularies and best practice guidelines by the tools and resources developed by the IDP community.

Current projects of the PSI-IDP working group are:

  • definition and development of the MIADE guidelines.
  • definition and development of the PSI-IDP exchange formats, working together with the PSI-MI workgroup.
  • development of the PSI-IDP controlled vocabulary to describe the technical aspects of IDP experiments and the sequence-level structural inferences derived from them.

Goals/Milestones

Goal 1: Completion of the MIADE standard defining the minimal fundamental parameters to describe a disorder experiment, based on simple use cases

Goal 2: Completion of the 1.0 version of the PSI-IDP TAB exchange format to represent, in a simple but unambiguous manner, an entry adhering to the MIADE guidelines for the description of the structural state of a protein region

Goal 3: Completion of the 1.0 version of the PSI-IDP XML and JSON exchange formats to enable the unequivocal representation of the experimental setup and results of analyses investigating the structural state of a protein region

Goal 4: Work together with the PSI-MI Working Group to set up a protocol for integrating data describing interactions mediated by IDRs into core data resources for molecular interactions

Goal 5: Defining the scope and priorities for version 1.0 of the controlled vocabulary for IDP exchange formats and develop the controlled vocabulary required for 1.0 version of the PSI-IDP exchange formats.

Milestone 1: Submission of a manuscript to announce the PSI-IDP Working Group

Milestone 2: Setting up the PSI-IDP Working Group website/GitHub page to serve as a platform for the dissemination of developed exchange formats, standards, guidelines and controlled vocabularies

Website
http://www.psidev.info/groups/intrinsically-disordered-proteins

Tags
Intrinsic Disorder, Intrinsically Disordered Proteins, Intrinsically Disordered Regions, Protein Structure, Protein Interactions, Protein Function