Quality Control

View documents for this group

HUPO Proteomics Standards Initiative
Quality Control Working Group (PSI-QC)


  1. Quality Control Group Charter
  2. Group Structure (2017)
  3. Formats, Definitions, and Metrics
  4. Getting Involved


The PSI Quality Control workgroup is one of the working groups of the Proteomics Standards Initiative.


Quality Control Group Charter

Focus and Purpose

The PSI-QC working group is composed of academic, government, and industry researchers, software developers, journal representatives, and instrument manufacturers. The main goal of the PSI-QC working group is to define a community data format and associated controlled vocabulary terms, facilitating data exchange and archiving of mass spectrometry derived quality control metrics.

Current projects of the PSI-QC working group are:

  • The mzQC format, which has been developed as a standardized format for the exchange, transmission, and archiving of quality control metrics derived from mass spectrometry.
  • Controlled Vocabulary development: controlled vocabulary terms are developed in common with the PSI-MS and PSI-PI groups.


  1. Submit a perspective manuscript to a journal in the field to announce the PSI-QC WG  (PubMed link)

  2. Analyze and revise the already published qcML format into a modern quality control data file format (mzQC)  √ 

  3. Submission of mzQC to the PSI document process √ 

  4. re-evaluate the CV terms used already for QC purposes, and consolidate the location for these terms in light of the existing PSI-MS CV √ 

  5. Implement validation strategies for mzQC documents with element content from various controlled vocabularies

  6. implement mzQC output from several freely available quality metric tools (e.g., QuaMeter, OpenMS)

  7. establish the revised mzQC format and associated CV terms as a HUPO-PSI standard



Group Structure (2017)

Current Incumbent
Chair David L. Tabb
Co-chair Mathias Walzer, Wout Bittremieux
MIAPE Co-ordinator Weimin Zhu, Reza Salek
Ontology Co-ordinator Julian Uszkoreit
Editor Stefan Tenzer
Secretary Wout Bittremieux
Website Maintainer Mathias Walzer
MaxQuant liaison Chris Bielow


Formats, Definitions, and Metrics

You can find the ongoing work and older versions of the mzQC format, term definitions, and metric designs on our HUPO-PSI GitHub page.

Getting Involved

If you would like to contribute to the work of the Quality Control workgroup, or just to receive the occasional email when a new version of a format becomes available, please contact us on psidev-qc-dev [at] lists.sourceforge.net or our GitHub page.


We would like to kindly acknowledge the valueable help the PSI-QC working group has recieved over the course of its work: