Intrinsically Disordered Proteins Working Group Charter
1. Administrative Section
Status (New/Update): New
HUPO PSI Intrinsically Disordered Proteins Working Group (PSI-IDP WG)
Chair (with affiliation and current email address):
Norman Davey - The Institute of Cancer Research, London, UK (firstname.lastname@example.org)
Co-Chairs (1 or 2) (with affiliation and current email address):
Silvio C. E. Tosatto - University of Padua, Padua, Italy (email@example.com)
Zsuzsanna Dosztányi - Eötvös Loránd University, Budapest, Hungary (firstname.lastname@example.org)
Bálint Mészáros - Eötvös Loránd University, Budapest, Hungary (email@example.com)
Other officers (optional) (with affiliation and current email address):
Editor(s): Nicolás Palopoli - Universidad Nacional de Quilmes, Buenos Aires, Argentina (firstname.lastname@example.org), Rita Pancsa - Research Centre for Natural Sciences, HAS, Budapest, Hungary (email@example.com), Kim Van Roey - European Molecular Biology Laboratory, Heidelberg, Germany (firstname.lastname@example.org)
Minimal Reporting Requirements Coordinator(s): Norman Davey - The Institute of Cancer Research, London, UK (email@example.com)
Ontology Coordinator(s): Toby Gibson - European Molecular Biology Laboratory, Heidelberg, Germany (firstname.lastname@example.org); Peter Tompa - Vrije Universiteit Brussel, Brussels, Belgium (email@example.com)
Website Maintainer(s): Damiano Piovesan - University of Padua, Padua, Italy (firstname.lastname@example.org)
2. Description and objectives
Focus and Purpose
The PSI-IDP working group is composed of academic, government, and industry researchers, software developers, and database curators and managers. The main goals of the PSI-IDP working group are to:
- define the community PSI-IDP XML, JSON and TAB exchange formats to permit the dissemination and storage of data relating to Intrinsically Disordered Proteins/Regions (IDP/IDR) structure and function.
- define the Minimum Information About Disordered Experiments (MIADE) guidelines to standardise the description of IDP experiments.
- create the ontologies and controlled vocabularies required to define the functional and structural aspects of IDRs, and the technical aspects of the exchange formats and minimum information guidelines.
- define the best practice guidelines for the curation of IDP literature and the annotation of IDP data.
- support the implementation of the PSI-IDP exchange formats, controlled vocabularies and best practice guidelines by the tools and resources developed by the IDP community.
Current projects of the PSI-IDP working group are:
- definition and development of the MIADE guidelines.
- definition and development of the PSI-IDP exchange formats, working together with the PSI-MI workgroup.
- development of the PSI-IDP controlled vocabulary to describe the technical aspects of IDP experiments and the sequence-level structural inferences derived from them.
Goal 1: Completion of the MIADE standard defining the minimal fundamental parameters to describe a disorder experiment, based on simple use cases
Goal 2: Completion of the 1.0 version of the PSI-IDP TAB exchange format to represent, in a simple but unambiguous manner, an entry adhering to the MIADE guidelines for the description of the structural state of a protein region
Goal 3: Completion of the 1.0 version of the PSI-IDP XML and JSON exchange formats to enable the unequivocal representation of the experimental setup and results of analyses investigating the structural state of a protein region
Goal 4: Work together with the PSI-MI Working Group to set up a protocol for integrating data describing interactions mediated by IDRs into core data resources for molecular interactions
Goal 5: Defining the scope and priorities for version 1.0 of the controlled vocabulary for IDP exchange formats and develop the controlled vocabulary required for 1.0 version of the PSI-IDP exchange formats.
Milestone 1: Submission of a manuscript to announce the PSI-IDP Working Group
Milestone 2: Setting up the PSI-IDP Working Group website/GitHub page to serve as a platform for the dissemination of developed exchange formats, standards, guidelines and controlled vocabularies
Intrinsic Disorder, Intrinsically Disordered Proteins, Intrinsically Disordered Regions, Protein Structure, Protein Interactions, Protein Function